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Tomoko Smyth Selected Research

ASTX-660

10/2021Antagonism of inhibitors of apoptosis proteins reveals a novel, immune response-based therapeutic approach for T-cell lymphoma.
1/2021Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
1/2018ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.

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Tomoko Smyth Research Topics

Disease

8Neoplasms (Cancer)
12/2020 - 07/2010
2Inflammation (Inflammations)
01/2021 - 12/2008
2Melanoma (Melanoma, Malignant)
01/2018 - 12/2014
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2016 - 03/2012
1T-Cell Lymphoma (Lymphoma, T Cell)
10/2021
1Colorectal Neoplasms (Colorectal Cancer)
01/2021
1Diarrhea
12/2020
1Fatigue
12/2020
1Nausea
12/2020
1Vomiting
12/2020
1Mucositis
12/2020
1Prostatic Neoplasms (Prostate Cancer)
01/2016
1Nasopharyngeal Carcinoma
10/2013
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
08/2012
1Carcinoma (Carcinomatosis)
03/2012
1Lung Neoplasms (Lung Cancer)
03/2012
1Leukemia
09/2010
1Myeloproliferative Disorders (Myeloproliferative Disorder)
07/2010
1Salmonella Infections (Salmonellosis)
12/2008
1Infections
12/2008
1Necrosis
03/2006

Drug/Important Bio-Agent (IBA)

8Proteins (Proteins, Gene)FDA Link
10/2021 - 03/2006
7(2,4- dihydroxy- 5- isopropylphenyl)- (5- (4- methylpiperazin- 1- ylmethyl)- 1,3- dihydroisoindol- 2- yl)methanoneIBA
12/2020 - 03/2012
3ASTX-660IBA
10/2021 - 01/2018
2Tyrosine Kinase InhibitorsIBA
10/2016 - 09/2010
2Imatinib Mesylate (Gleevec)FDA Link
08/2012 - 09/2010
1Inhibitor of Apoptosis ProteinsIBA
10/2021
1CaspasesIBA
01/2021
1Histone Deacetylases (Histone Deacetylase)IBA
01/2021
13- (2- (2- tert- butylphenylaminooxalyl)aminopropionylamino)- 4- oxo- 5- (2,3,5,6- tetrafluorophenoxy)pentanoic acidIBA
01/2021
1Caspase 10IBA
01/2021
1Fluorouracil (Carac)FDA LinkGeneric
01/2021
1Caspase 8 (Caspase-8)IBA
01/2021
14- (2,6- dichlorobenzoylamino)- 1H- pyrazole- 3- carboxylic acid piperidin-4-ylamideIBA
12/2020
1Pharmaceutical PreparationsIBA
12/2020
1Biomarkers (Surrogate Marker)IBA
12/2020
1PeptidomimeticsIBA
01/2018
1Erlotinib Hydrochloride (CP 358,774)FDA Link
10/2016
1CrizotinibIBA
10/2016
1Hormones (Hormone)IBA
01/2016
1AndrogensIBA
01/2016
1Androgen Receptors (Androgen Receptor)IBA
01/2016
1RNA (Ribonucleic Acid)IBA
01/2016
1Messenger RNA (mRNA)IBA
01/2016
1VemurafenibIBA
12/2014
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
12/2014
1Phosphotransferases (Kinase)IBA
12/2014
1Heat-Shock Proteins (Heat-Shock Protein)IBA
03/2012
1Lactic Acid (Lactate)FDA LinkGeneric
03/2012
1SaltsIBA
03/2012
1Isoleucine (L-Isoleucine)FDA Link
09/2010
1Threonine (L-Threonine)FDA Link
09/2010
1Janus KinasesIBA
07/2010
11- cyclopropyl- 3- (3- (5- morpholin- 4- ylmethyl- 1H- benzoimidazol- 2- yl)- 1H- pyrazol- 4- yl)ureaIBA
07/2010
1Aurora KinasesIBA
07/2010
1LipopolysaccharidesIBA
12/2008
1GlucocorticoidsIBA
12/2008
1Dexamethasone (Maxidex)FDA LinkGeneric
12/2008
1SteroidsIBA
12/2008
1Toll-Like Receptor 4IBA
12/2008
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
03/2006
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2006

Therapy/Procedure

2Aftercare (After-Treatment)
08/2012 - 03/2012
1Adjuvant Chemotherapy
01/2021
1Therapeutics
01/2016